Functional characteristics of LDL particles derived from various LDL-apheresis techniques regarding LDL-drug-complex preparation.
نویسندگان
چکیده
منابع مشابه
LDL-Apheresis: Technical and Clinical Aspects
The prognosis of patients suffering from severe hyperlipidemia, sometimes combined with elevated lipoprotein (a) levels, and coronary heart disease refractory to diet and lipid-lowering drugs is poor. For such patients, regular treatment with low-density lipoprotein (LDL) apheresis is the therapeutic option. Today, there are five different LDL-apheresis systems available: cascade filtration or ...
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Extracorporeal reduction of plasma low density lipoproteins (LDLs) by LDL apheresis was shown to attenuate the proatherogenic influences of LDL, such as impairment of vasodilation and increased monocyte adhesion to the endothelium. In 16 patients with familial hypercholesterolemia, we analyzed whether LDL apheresis by the heparin precipitation procedure affected the oxidative resistance of LDL....
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Epidemiologic studies and in vitro experiments indicate that low density lipoprotein (LDL) subtypes differ concerning their atherogenic potential. Small, dense LDL are more atherogenic than large, buoyant LDL. LDL apheresis is a potent therapeutic modality to lower elevated LDL-cholesterol. It is unknown whether such therapy induces a shift in the LDL subtype distribution. In this study we eval...
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Plasmapheresis is one of the methods of extracorporeal blood purification used for many decades for the treatment of different kidney and extrarenal diseases, mainly of autoimmunological nature. The main disadvantage of this method is the lack of selectivity and the risk of infections associated with plasma used for supplementation. Hence, the efforts are made to establish an alternative blood ...
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In the present study we try to define the optimal conditions for preparation of copper-oxidized low-density lipoprotein (oxLDL) to be used for the assay of oxLDL antibodies by enzyme immunoassay (EIA). Oxidation of LDL was monitored by measuring the formation of conjugated dienes at 234 nm and the generation of fluorescent products with emission at 430 nm when excitation is performed at 360 nm....
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1990
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)42115-7